The Laboratory of cancer cell biology (LCCB), a joint workplace of the 1st Faculty of Medicine, Charles University and The Institute of Physiology of the Academy of Sciences of the Czech Republic, opens positions for PhD students in biochemistry and pathobiochemistry (see details)
LCCB is an association of Laboratory of cell and molecular biology (Institute of Biochemistry and Experimental Oncology, 1st Faculty of Medicine, Charles University) and the Laboratory of Growth and Differentiation of Cell Populations (The Institute of Physiology of the Academy of Sciences of the Czech Republic). LCCB actively takes part in a number of national and international cooperation’s. The interconnection between the University and The Academy provides a wide range of methodical support, experienced tutors and a contiguity with the clinical medicine.
The projectsof LCCB are targeted at the mechanisms underlining the regulation of cell growth, differentiation and transformation. From this point there is a specific interest in the group of multifunctional proteins "dipeptidylpeptidase-IV activity and/or structure homologues" (DASH). The current pieces of knowledge point to crucial significance of these molecules in the pathogenesis of a number of diseases including autoimmune diseases and tumors. The characterization of their properties and function mechanisms is the prerequisite for their use as therapeutic targets. In the past years, the laboratory participated on the definition of this group of molecules as a whole and on assessing the functional characteristics of its selected representatives on the basis of its own experimental data and in cooperation with partners abroad.
An ideal candidate: A motivated graduate of the Medical Faculty or a Faculty of Sciences, complying with the general requirements for a PhD student, with a profound interest in scientific work in the borderland between biochemistry and cell and molecular biology, capable of a highly creative activity. Previous experience in molecular biology methods, cell culture or microscopy is welcomed, nevertheless can be to a certain extent compensated by a trustworthy determination, ability to learn quickly and a high frustration threshold.
We offer: high-quality projects, equipment and good relations among the members of the team.
Selected papers:see team
Prof. Aleksi Šedo, MD, DSc, head of LCCB
e-mail: Aleksi@cesnet.cz, Tel/Fax.: +42022496 5826
The poster entitled „Expression of fibroblast activation protein in human glioblastomas and its role in the interaction of glioma cells with the proteins of extracellular matrix“ was awarded a „Best Poster“ Award at the ASBMB (American Society for Biochemistry and Molecular Biology) Special Symposium Membrane-Anchored Serine Proteases, held at The Bolger Center, Potomac, MD, USA on September 19-22, 2013.
LCCB participates on preparation of Biotechnology and Biomedicine Centre, centre of excellence of Academy of Sciences and Charles University more: www.biocev.eu
Repercussion of LCCB work can be viewed here http://research.dfci.harvard.edu/attractin/ section Bibliography a People
LCCB is a founding member of the Neurooncological section of the Czech Oncological Society of the Czech Medical Association of J.E. Purkyně (http://www.linkos.cz/odborne-sekce-cos/neuroonkologicka-sekce). The section should facilitate the national and international cooperation between clinical and biomedical disciplines that participate on the diagnostics, treatment and research of malignancies affecting the central nervous system.
LCCB is constituent member Association for Experimental Studies in Oncologywith aim tu facilitate interdisciplinar and interinstitutional colaboration in research and development of avanced cancer therapies.