Search for PhD students

The Laboratory of cancer cell biology (LCCB), a joint workplace of the 1st Faculty of Medicine, Charles University and The Institute of Physiology of the Academy of Sciences of the Czech Republic, opens positions for PhD students in biochemistry and pathobiochemistry

LCCB is an association of Laboratory of cell and molecular biology (Institute of Biochemistry and Experimental Oncology, 1st Faculty of Medicine, Charles University) and the Laboratory of Growth and Differentiation of Cell Populations (The Institute of Physiology of the Academy of Sciences of the Czech Republic). LCCB actively takes part in a number of national and international cooperation’s. The interconnection between the University and The Academy provides a wide range of methodical support, experienced tutors and a contiguity with the clinical medicine.

The projects of LCCB are targeted at the mechanisms underlining the regulation of cell growth, differentiation and transformation. From this point there is a specific interest in the group of multifunctional proteins "dipeptidylpeptidase-IV activity and/or structure homologues" (DASH). The current pieces of knowledge point to crucial significance of these molecules in the pathogenesis of a number of diseases including autoimmune diseases and tumors. The characterization of their properties and function mechanisms is the prerequisite for their use as therapeutic targets. In the past years, the laboratory participated on the definition of this group of molecules as a whole and on assessing the functional characteristics of its selected representatives on the basis of its own experimental data and in cooperation with partners abroad.

An ideal candidate: A motivated graduate of the Medical Faculty or a Faculty of Sciences, complying with the general requirements for a PhD student, with a profound interest in scientific work in the borderland between biochemistry and cell and molecular biology, capable of a highly creative activity. Previous experience in molecular biology methods, cell culture or microscopy is welcomed, nevertheless can be to a certain extent compensated by a trustworthy determination, ability to learn quickly and a high frustration threshold.

We offer: high-quality projects, equipment and good relations among the members of the team.

Selected papers: see team


Prof. Aleksi Šedo, MD, PhD, head of LCCB
e-mail:, Tel/Fax.: +42022496 5826


LCCB participates on preparation of Biotechnology and Biomedicine Centre, centre of excellence of Academy of Sciences and Charles University more:

Repercussion of LCCB work can be viewed here section Bibliography a People

LCCB is constituent member Association for Experimental Studies in Oncology with aim tu facilitate interdisciplinar and interinstitutional colaboration in research and development of avanced cancer therapies.